In the folder where LISA is installed, usually C:\Program Files (x86)\LISA_FET\LISA80; right click the file "lisa8.exe" then select "properties".

On the dialog that appears select the "compatibility" tab. Then select the check-box for "run this program in compatibility mode for:", then, from the drop down list select Windows 10 . Do the same for the file "ngmeshb.exe".

There are other options on this tab that can be used if needed such as "reduced color mode" and "run this program as an administrator".